Natural History Samples Catalogue
Definitions:
ND: Newly Diagnosed Participants. All ND participants had a baseline assessment within 6 weeks from diagnosis of T1D (based on the ADA criteria, defined as the time at which insulin therapy was started).
UFM: Unaffected Family Members. Participants who have a first-degree relative with T1D and tested positive for Islet autoantibodies (IAb+). The UFM DNA samples correspond to all screened UFMs, regardless of IAb status.
Follow-up visit schedule for ND and UFM participants:
Tube and aliquot volume per sample type:
- Serum: FluidX, 0.5 ml/aliquot
- EDTA Plasma: FluidX, 0.2 ml/aliquot
- DNA: FluidX (from EDTA plasma), 0.5 ml/aliquot
- Urine: FluidX, 1 ml/aliquot
- Whole Blood: PAXgene, 10 ml/aliquot
- Stool: OMNIgene-GUT, 10 ml/aliquot
Samples (with at least one aliquot) available per Visit and Sample Type
| Visit | Serum | EDTA Plasma | DNA | Urine | Whole Blood (RNA) | Stool |
|---|---|---|---|---|---|---|
| ND Participants | ||||||
| Visit 1 | 331 | 267 | 602 | 501 | 269 | 325 |
| Visit 2 | 499 | 0 | 0 | 475 | 0 | 332 |
| Visit 3 | 448 | 0 | 0 | 435 | 0 | 293 |
| Visit 4 | 243 | 152 | 0 | 377 | 170 | 229 |
| Visit 5 | 215 | 108 | 0 | 278 | 259 | 119 |
| UFM Participants | ||||||
| Visit 1 | 198 | 116 | 4701 | 281 | 191 | 53 |
| Visit 2 | 227 | 0 | 0 | 0 | 0 | 73 |
| Visit 3 | 119 | 83 | 0 | 190 | 112 | 53 |
| Visit 4 | 147 | 0 | 0 | 0 | 0 | 37 |
| Visit 5 | 89 | 47 | 0 | 111 | 80 | 41 |
| Visit 6 | 54 | 23 | 0 | 65 | 62 | 41 |
| Visit 7 | 30 | 11 | 0 | 33 | 33 | 25 |